Kinases are specialized enzymes that transfer phosphate groups from ATP to a substrate. The most often studied kinases are protein kinases, which are generally subdivided into tyrosine, and serine/threonine-directed kinases. As such, kinases are key signal transduction molecules relevant in almost every cellular process from cellular proliferation to DNA repair. Kinases alterations have been identified in many cancers (often as oncogenes) but also in several non-cancer diseases.
Kinase inhibitors are a quickly expanding therapeutic modality in cancer and inflammatory diseases. More information will be posted soon!