Our Recent Kinomics Publications:

Kinomics Publications:

  1. Anderson JC*, Willey CD*, Mehta A, Welaya K, Chen D, Duarte CW, Ghatalia P, Arafat W, Madan A, Sudarshan S, Naik G, Grizzle WE, Choueiri TK, Sonpavde G. High throughput kinomic profiling of human clear cell renal cell carcinoma identifies kinase activity dependent molecular subtypes. PLoS One. 2015 Sep 25;10(9):e0139267. doi: 10.1371/journal.pone.0139267. eCollection 2015. PMID: 26406598
  1. Anderson JC, Taylor R, Gillespie GY, Fiveash JB, Willey CD. Exploration of Kinomic Signaling in Atypical Meningioma. Medical Research Archives. Med Res Arch. 2015 Jul;2015(3). doi: 10.18103/mra.v0i3.104. PMID: 27158663
  1. Willey CD, Gilbert A, Anderson JC, Gillespie GY. Patient-Derived Xenografts as a Model System for Radiation Research. Semin Radiat Oncol. 2015 Oct;25(4):273-80. doi: 10.1016/j.semradonc.2015.05.008. Epub 2015 May 14. Review. PMID: 26384275
  1. Stoltz K, Sinyuk M, Hale JS, Wu Q, Otvos B, Walker K, Vasanji A, Rich JN, Hjelmeland AB, Lathia JD. Development of a Sox2 reporter system modeling cellular heterogeneity in glioma. Neuro Oncol. 2015;17(3):361-71. doi: 10.1093/neuonc/nou320. PMID: 25416826
  1. Seu L, Sabbaj S, Duverger A, Wagner F, Anderson JC, Davies E, Wolschendorf F, Willey CD, Saag MS, Goepfert P, Kutsch O. Stable Phenotypic Changes of the Host T Cells are Essential to the Long-term Stability of Latent HIV-1 Infection. J Virol. 2015 Jul;89(13):6656-72. PMID: 25878110
  1. Anderson JC, Minnich DJ, Dobelbower MC, Denton AJ, Dussaq AM, Gilbert AN, Rohrbach TD, Arafat W, Welaya K, Bonner JA, Willey CD. Kinomic Profiling of Electromagnetic Navigational Bronchoscopy Specimens: A New Approach for Personalized Medicine. PLoS One. 2014 Dec 30;9(12):e116388. doi: 10.1371/journal.pone.0116388. eCollection 2014. PMID: 25549342
  1. Isayeva T, Xu J, Ragin C, Dai Q, Cooper T, Carroll W, Dayan D, Vered M, Wenig B, Rosenthal E, Grizzle W, Anderson JC, Willey CD, Yang ES, Brandwein-Gensler M. The Protective Effect of p16Ink4A in Oral Cavity Carcinomas: p16Ink4A Dampens Tumor Invasion: Integrated Analysis of Expression and Kinomics Pathways. Mod Pathol. 2014 Dec 19. doi: 10.1038/modpathol.2014.149. PMID: 25523612
  1. Anderson JC, Duarte CW, Welaya K, Rohrbach TD, Bredel M, Yang ES, Choradia NV, Thottassery JV, Yancey Gillespie G, Bonner JA, Willey CD. Kinomic exploration of temozolomide and radiation resistance in Glioblastoma multiforme xenolines. Radiother Oncol. 2014 May 8. pii: S0167-8140(14)00173-X. doi: 10.1016/j.radonc.2014.04.010. PMID: 24813092
  1. Duverger A, Wolschendorf F, Anderson JC, Wagner F, Bosque A, Shishido T, Jones J, Planelles V, Willey CD, Cron RQ, Kutsch O. Kinase control of Latent HIV-1 Infection: PIM-1 Kinase as a Major Contributor to HIV-1 Reactivation. J Virol. 2013 Jan;88(1):364-76. doi: 10.1128/JVI.02682-13. PubMed PMID: 24155393
  1. Jarboe JS*, Jaboin JJ*, Anderson JC, Nowsheen S, Stanley JA, Naji F, Ruijtenbeek R, Tu T, Hallahan DE, Yang ES, Bonner JA, Willey CD. Kinomic profiling approach identifies Trk as a novel radiation modulator. Radiother Oncol. 2012 Jun;103(3):380-7. Epub 2012 May 5. PMID: 22561027


1. Mehta AN, Willey C, Crowley M, Anderson J, Chen D, Crossman D, Necchi A, di Lorenzo G, Eigl BJ, Lee RJ, Harshman LC, Dorff TB, Galsky MD, Milowsky MI, Bolger G, DeShazo M, Naik G, Grizzle WE, Sonpavde G. Integrated comprehensive high-throughput kinomics profiling and whole exome sequencing of penile squamous cell cancer (PSCC). ASCO Meeting Abstracts. 2014;32(4_suppl):383.

2. Mehta AN, Willey CD, Anderson J, Welaya KY, Chen D, Ghatalia P, Madan A, Sudarshan S, Naik G, Grizzle WE, Choueiri TK, Sonpavde G. Comprehensive kinase profiling to classify clear cell (cc)-renal cell carcinoma (RCC). ASCO Meeting Abstracts. 2014;32(4_suppl):409.

3. Arafat WO, Anderson J, Welaya K, Willey C, Gillespie Y, Buchsbaum D. Triple Therapy Using Radiation Therapy (RT), Temozolomide (TMZ), and TRAIL Agonist (TRA-8) Enhances Cell Killing in Primary Glioma Cancer Stem Cells Associated With Changes in Distinct Tyrosine Kinase Signaling Cascades Identified Through Kinomic Analysis. International journal of radiation oncology, biology, physics. 2013;87(2):S140.

4. G. Sonpavde, J.C. Anderson, K. Welaya, D. Chen, A. Mehta, P. Ghatalia, S. Sudarshan, W.E. Grizzle, T.K. Choueiri, C.D. Willey. Comprehensive activated kinase profiling to identify novel therapeutic targets in metastatic clear cell (cc)-renal cell carcinoma (RCC). Poster Presentation at the European Cancer Congress 2013.

5.  Huang Z-Q, Anderson J, Rohrbach, TD, Hall, SD, Brown RT, Julian BA, Willey CD, Novak J. Characterization of Signaling Pathways in Cultured Human Mesangial Cells Induced by IgA1-containing Immune Complexes from Patients with IgA Nephropathy. J. Am. Soc. Nephrol. 23, 824A, 2012.

6. Anderson J, Duarte C, Naji F, Bouwmeester R, Rohrbach T, de wijn R, Willey CD. Kinomic Profiling Identifies Pathways of HER2 Targeted Therapy Resistance in HER2 Positive Breast Cancer Cell Lines. International Journal of Radiation Oncology* Biology* Physics 84 (3S), S23 (2012).

7. Willey CD, Anderson JC, Duarte CW, Zhi D, Cui X, Choradia NV, Srinivasainagendra V, Wang J, Gillespie G. Kinomic Proband Model of Radiation Response from Patient-Derived GBM Xenolines. International Journal of Radiation Oncology* Biology* Physics 84, (3S) S178-9 (2012).

8.  Lerma L.A., Anderson J.C., Xu C., Kao M., Kim K.H., MS, Annis J., Rohrbach T.D., Grandori C., Willey C.D., Méndez E. Kinome profiling identifies novel therapeutic targets in p53-mutant, metastatic head and neck squamous cell carcinoma. Oral Presentation at the 8th International Conference on Head and Neck Cancer, July 2012.

9.  Huang Z-Q, Anderson J, Hall, SD, Rohrbach, TD, Brown RT, Julian BA, Willey CD, Novak J. Immune Complexes from Patients with IgA Nephropathy Containing Galactose-Deficient IgA1 and Anti-glycan Antibodies Induce Protein-kinase Signaling and Proliferation in Cultured Human Mesangial Cells. J. Am. Soc. Nephrol. 22, 531A, 2011.

10. Gillespie, G.Y.,  Duarte,  C.W.,  Willey, C.D., Zhi, D., Cui,  X., Anderson, J.C.,  Yamshchikov, V.,  Langford, C., Mehta, T., Srinivasasainagendra, V., Wang, J., Sambandam, V., Thottassery, J.V.  Integrated ‘Omics of Patient-Derived GBM Xenolines: Proband Models For Personalized Medicine.  SAIC/NCI GBM Workshop, September 2011.

11. Huang Z-Q, Anderson J, Hall, SD, Rohrbach, TD, Brown RT, Julian BA, Willey CD, Novak J. Protein-kinase Inhibitors Can Block Cellular Proliferation and Signaling Induced in Cultured Human Mesangial Cells by Immune Complexes from Patients with IgA Nephropathy. J. Am. Soc. Nephrol. 22, 531A, 2011.

12.  Willey CD, Tu T, Jaboin J, Ruijtenbeek R, Hallahan DE: Kinomic analysis identifies trk as a target for modulation of radiation sensitization in vascular endothelium. International Journal of Radiation Oncology Biology Physics 72:S62-S62, 2008.