Recent Kinomics Publications:

Publications from Us, Our Collaborators, and Our Clients.

  1. Pepin ME, Padgett LE, McDowell RE, Burg A, Brahma MK, Holleman C, Kim T, Crossman D, Kutsch O, Tse HM, Wende AR, Habegger KM. Antiretroviral therapy potentiates high-fat diet induced obesity and glucose intolerance. Mol Metab. 2018 Jun; 12: 48–61. Published online 2018 Apr 20. doi: 10.1016/j.molmet.2018.04.006. PMID: 29731256
  2. Walker K, Boyd NH, Anderson JC, Willey CD, Hjelmeland AB. Kinomic profiling of glioblastoma cells reveals PLCG1 as a target in restricted glucose. Biomark Res. 2018 Jun 14;6:22. doi: 10.1186/s40364-018-0136-9. eCollection 2018. PMID: 29946469
  3. Gilbert AN, Anderson JC, Duarte CW, Shevin RS, Langford CP, Singh R, Gillespie GY, Willey CD. Combinatorial Drug Testing in 3D Microtumors Derived from GBM Patient-Derived Xenografts Reveals Cytotoxic Synergy in Pharmacokinomics-informed Pathway Interactions. Sci Rep. 2018 May 30;8(1):8412. doi: 10.1038/s41598-018-26840-4. PMID: 29849102
  4. Britain CM, Holdbrooks AT, Anderson JC, Willey CD, Bellis SL. Sialylation of EGFR by the ST6Gal-I sialyltransferase promotes EGFR activation and resistance to gefitinib-mediated cell death. J Ovarian Res. 2018 Feb 5;11(1):12. doi: 10.1186/s13048-018-0385-0. PMID: 29402301
  5. Yamada K, Huang ZQ, Raska M, Reily C, Anderson JC, Suzuki H, Ueda H, Moldoveanu Z, Kiryluk K, Suzuki Y, Wyatt RJ, Tomino Y, Gharavi AG, Weinmann A, Julian BA, Willey CD, Novak J. Inhibition of STAT3 Signaling Reduces IgA1 Autoantigen Production in IgA Nephropathy. Kidney Int Rep. 2017 Jul 19;2(6):1194-1207. doi: 10.1016/j.ekir.2017.07.002. eCollection 2017 Nov. PMID: 29270528
  6. Ghosh AP, Willey CD, Anderson JC, Welaya K, Chen D, Mehta A, Ghatalia P, Madan A, Naik G, Sudarshan S, Sonpavde G. Kinomic profiling identifies focal adhesion kinase 1 as a therapeutic target in advanced clear cell renal cell carcinoma. Oncotarget. 2017 Apr 25;8(17):29220-29232. doi: 10.18632/oncotarget.16352. PMID: 28418903
  7. McGuire JL, Depasquale EA, Funk AJ, O’Donnovan SM, Hasselfeld K, Marwaha S, Hammond JH, Hartounian V, Meador-Woodruff JH, Meller J, McCullumsmith RE. Abnormalities of signal transduction networks in chronic schizophrenia. NPJ Schizophr. 2017; 3: 30. Published online 2017 Sep 12. doi: 10.1038/s41537-017-0032-6. PMID: 28900113
  8. Yang ES, Willey CD, Mehta A, Crowley MR, Crossman DK, Chen D, Anderson JC, Naik G, Della Manna DL, Cooper TS, Sonpavde G. Kinase analysis of penile squamous cell carcinoma on multiple platforms to identify potential therapeutic targets. Oncotarget. 2017 Mar 28;8(13):21710-21718. doi: 10.18632/oncotarget.15558. PMID: 28423512
  9. Dorsett CR, McGuire JL, Niedzielko TL, DePasquale EA, Meller J, Floyd CL, McCullumsmith RE. Traumatic Brain Injury Induces Alterations in Cortical Glutamate Uptake without a Reduction in Glutamate Transporter-1 Protein Expression. J Neurotrauma. 2017 Jan 1; 34(1): 220–234. Published online 2017 Jan 1. doi: 10.1089/neu.2015.4372. PMID: 27312729
  10. Gilbert AN, Shevin RS, Anderson JC, Langford CP, Eustace N, Gillespie GY, Singh R, Willey CD. Generation of Microtumors Using 3D Human Biogel Culture System and Patient-derived Glioblastoma Cells for Kinomic Profiling and Drug Response Testing. J Vis Exp. 2016 Jun 9;(112). doi: 10.3791/54026. PMID: 27341166
  11. Dussaq A, Anderson JC, Willey CD, Almeida JS. Mechanistic Parameterization of the Kinomic Signal in Peptide Arrays. J Proteomics Bioinform. 2016 May;9(5):151-157. Epub 2016 May 24. PMID: 27601856
  12. McGuire JL, Hammond JH, Yates SD, Chen D, Haroutunian V, Meador-Woodruff JH, McCullumsmith RE. Altered Serine/Threonine Kinase Activity in Schizophrenia. Brain Res. 2014 Jun 3; 1568: 42–54. Published online 2014 Apr 26. doi: 10.1016/j.brainres.2014.04.029. PMID: 24780530
  13. Anderson JC*, Willey CD*, Mehta A, Welaya K, Chen D, Duarte CW, Ghatalia P, Arafat W, Madan A, Sudarshan S, Naik G, Grizzle WE, Choueiri TK, Sonpavde G. High throughput kinomic profiling of human clear cell renal cell carcinoma identifies kinase activity dependent molecular subtypes. PLoS One. 2015 Sep 25;10(9):e0139267. doi: 10.1371/journal.pone.0139267. eCollection 2015. PMID: 26406598
  14. Anderson JC, Taylor R, Gillespie GY, Fiveash JB, Willey CD. Exploration of Kinomic Signaling in Atypical Meningioma. Medical Research Archives. Med Res Arch. 2015 Jul;2015(3). doi: 10.18103/mra.v0i3.104. PMID: 27158663
  15. Willey CD, Gilbert A, Anderson JC, Gillespie GY. Patient-Derived Xenografts as a Model System for Radiation Research. Semin Radiat Oncol. 2015 Oct;25(4):273-80. doi: 10.1016/j.semradonc.2015.05.008. Epub 2015 May 14. Review. PMID: 26384275
  16. Stoltz K, Sinyuk M, Hale JS, Wu Q, Otvos B, Walker K, Vasanji A, Rich JN, Hjelmeland AB, Lathia JD. Development of a Sox2 reporter system modeling cellular heterogeneity in glioma. Neuro Oncol.2015;17(3):361-71. doi: 10.1093/neuonc/nou320. PMID: 25416826
  17. Seu L, Sabbaj S, Duverger A, Wagner F, Anderson JC, Davies E, Wolschendorf F, Willey CD, Saag MS, Goepfert P, Kutsch O. Stable Phenotypic Changes of the Host T Cells are Essential to the Long-term Stability of Latent HIV-1 Infection. J Virol. 2015 Jul;89(13):6656-72. PMID: 25878110
  18. Anderson JC, Minnich DJ, Dobelbower MC, Denton AJ, Dussaq AM, Gilbert AN, Rohrbach TD, Arafat W, Welaya K, Bonner JA, Willey CD. Kinomic Profiling of Electromagnetic Navigational Bronchoscopy Specimens: A New Approach for Personalized Medicine. PLoS One.2014 Dec 30;9(12):e116388. doi: 10.1371/journal.pone.0116388. eCollection 2014. PMID: 25549342
  19. Isayeva T, Xu J, Ragin C, Dai Q, Cooper T, Carroll W, Dayan D, Vered M, Wenig B, Rosenthal E, Grizzle W, Anderson JC, Willey CD, Yang ES, Brandwein-Gensler M. The Protective Effect of p16Ink4A in Oral Cavity Carcinomas: p16Ink4A Dampens Tumor Invasion: Integrated Analysis of Expression and Kinomics Pathways. Mod Pathol.2014 Dec 19. doi: 10.1038/modpathol.2014.149. PMID: 25523612
  20. Anderson JC, Duarte CW, Welaya K, Rohrbach TD, Bredel M, Yang ES, Choradia NV, Thottassery JV, Yancey Gillespie G, Bonner JA, Willey CD. Kinomic exploration of temozolomide and radiation resistance in Glioblastoma multiforme xenolines. Radiother Oncol.2014 May 8. pii: S0167-8140(14)00173-X. doi: 10.1016/j.radonc.2014.04.010. PMID: 24813092
  21. Marballi KK, McCullumsmith RE, Yates SD, Escamilla MA, Leach RJ, Raventos H, Walss-Bass C. Global signaling effects of a schizophrenia-associated missense mutation in neuregulin 1: An exploratory study using whole genome and novel kinome approaches. J Neural Transm. 2014 May; 121(5): 479–490. Published online 2014 Jan 1. doi: 10.1007/s00702-013-1142-6.PMID: 24380930
  22. Duverger A, Wolschendorf F, Anderson JC, Wagner F, Bosque A, Shishido T, Jones J, Planelles V, Willey CD, Cron RQ, Kutsch O. Kinase control of Latent HIV-1 Infection: PIM-1 Kinase as a Major Contributor to HIV-1 Reactivation. J Virol.2013 Jan;88(1):364-76. doi: 10.1128/JVI.02682-13. PubMed PMID: 24155393
  23. Jarboe JS*, Jaboin JJ*, Anderson JC, Nowsheen S, Stanley JA, Naji F, Ruijtenbeek R, Tu T, Hallahan DE, Yang ES, Bonner JA, Willey CD. Kinomic profiling approach identifies Trk as a novel radiation modulator. Radiother Oncol.2012 Jun;103(3):380-7. Epub 2012 May 5. PMID: 22561027

Selected Abstracts:

  1. Mehta AN, Willey CD, Crowley M, Anderson JC, Chen D, Crossman D, Necchi A, diLorenzo G, Eigl BJ, Lee RJ, Harshman LC, Dorff TB, Galsky MD, Milowsky MI, Bolger G, DeShazo M, Naik G, Grizzle WE, Sonpavde G. Integrated comprehensive high-throughput kinomics profiling and whole exome sequencing of penile squamous cell cancer (PSCC). ASCO Meeting Abstracts. 2014;32(4_suppl):383.
  2. Mehta AN, Willey CD, Anderson J, Welaya KY, Chen D, Ghatalia P, Madan A, Sudarshan S, Naik G, Grizzle WE, Choueiri TK, Sonpavde G. Comprehensive kinase profiling to classify clear cell (cc)-renal cell carcinoma (RCC). ASCO Meeting Abstracts. 2014;32(4_suppl):409.
  3. Arafat WO, Anderson JC, Welaya KY, Willey CD, Gillespie GY, Buchsbaum D. Triple Therapy Using Radiation Therapy (RT), Temozolomide (TMZ), and TRAIL Agonist (TRA-8) Enhances Cell Killing in Primary Glioma Cancer Stem Cells Associated With Changes in Distinct Tyrosine Kinase Signaling Cascades Identified Through Kinomic Analysis. International journal of radiation oncology, biology, physics. 2013;87(2):S140.
  4. Sonpavde G, Anderson JC, Welaya KY, Chen D, Mehta A, Ghatalia P, Sudarshan S, Grizzle WE, Choueiri TK, Willey CD. Comprehensive activated kinase profiling to identify novel therapeutic targets in metastatic clear cell (cc)-renal cell carcinoma (RCC). Poster Presentation at the European Cancer Congress 2013.
  5.  Huang ZQ, Anderson JC, Rohrbach TD, Hall SD, Brown RT, Julian BA, Willey CD, Novak J. Characterization of Signaling Pathways in Cultured Human Mesangial Cells Induced by IgA1-containing Immune Complexes from Patients with IgA Nephropathy. J. Am. Soc. Nephrol. 23, 824A, 2012.
  6. Anderson JC, Duarte CW, Naji F, Bouwmeester R, Rohrbach T, deWijn R, Willey CD. Kinomic Profiling Identifies Pathways of HER2 Targeted Therapy Resistance in HER2 Positive Breast Cancer Cell Lines. International Journal of Radiation Oncology* Biology* Physics 84 (3S), S23 (2012).
  7. Willey CD, Anderson JC, Duarte CW, Zhi D, Cui X, Choradia NV, Srinivasainagendra V, Wang J, Gillespie GY. Kinomic Proband Model of Radiation Response from Patient-Derived GBM Xenolines. International Journal of Radiation Oncology* Biology* Physics 84, (3S) S178-9 (2012).
  8. Lerma LA, Anderson JC, Xu C, Kao M, Kim KH, Annis J, Rohrbach TD, Grandori C, Willey CD, Méndez E. Kinome profiling identifies novel therapeutic targets in p53-mutant, metastatic head and neck squamous cell carcinoma. Oral Presentation at the 8thInternational Conference on Head and Neck Cancer, July 2012.
  9. Huang ZQ, Anderson JC, Hall SD, Rohrbach TD, Brown RT, Julian BA, Willey CD, Novak J. Immune Complexes from Patients with IgA Nephropathy Containing Galactose-Deficient IgA1 and Anti-glycan Antibodies Induce Protein-kinase Signaling and Proliferation in Cultured Human Mesangial Cells. J. Am. Soc. Nephrol. 22, 531A, 2011.
  10. Gillespie GY, Duarte  CW,  Willey CD, Zhi D, Cui  X, Anderson JC,  Yamshchikov V,  Langford CL., Mehta T, Srinivasasainagendra V, Wang, J, Sambandam V, Thottassery, JV  Integrated ‘Omics of Patient-Derived GBM Xenolines: Proband Models For Personalized Medicine.  SAIC/NCI GBM Workshop, September 2011.
  11. Huang ZQ, Anderson JC, Hall SD, Rohrbach TD, Brown RT, Julian BA, Willey CD, Novak J. Protein-kinase Inhibitors Can Block Cellular Proliferation and Signaling Induced in Cultured Human Mesangial Cells by Immune Complexes from Patients with IgA Nephropathy. J. Am. Soc. Nephrol. 22, 531A, 2011.
  12. Willey CD, Tu T, Jaboin J, Ruijtenbeek R, Hallahan DE: Kinomic analysis identifies trk as a target for modulation of radiation sensitization in vascular endothelium. International Journal of Radiation Oncology Biology Physics 72:S62-S62, 2008.